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Dermatochalasis Through Decades: A Histopathologic Study
Mohsen Bahmani Kashkouli, Nasser Karimi1, Mohamad-Mehdi Johari-Moghadam1
1Eye Research Center, The Five Senses Institute.
Annals of Plastic Surgery
|February 8, 2021
Summary
Dermatochalasis (DC) histopathology is similar across age groups, but lymphatic vessel diameter increases with age. This suggests lymphangiectasia progresses with aging in patients undergoing blepharoplasty.
Area of Science:
- Ophthalmology
- Dermatology
- Pathology
Background:
- Dermatochalasis (DC) is associated with inflammation, elastolysis, and lymphostasis.
- Younger patients are increasingly seeking blepharoplasty, raising questions about age-related histopathological differences in DC.
Purpose of the Study:
- To histopathologically compare dermatochalasis in younger versus older patients undergoing blepharoplasty.
- To investigate age-related changes in eyelid skin histology, focusing on lymphatic vessels and elastic fibers.
Main Methods:
- Prospective case series of 20 women undergoing blepharoplasty, divided into two age groups (≤50 and >50 years).
- Histopathological examination of 60 upper eyelid specimens, analyzing skin thickness, lymphatic vessel diameter and density, elastic fiber density, and collagen characteristics.
- A masked pathologist evaluated all specimens.
Main Results:
- No significant differences in most histopathological measurements between the age groups.
- Mean lymphatic vessel diameter was significantly larger in the older group (>50 years) (P = 0.034).
- A positive correlation was found between age and lymphatic vessel diameter (rs = 0.3, P = 0.009).
Conclusions:
- Histopathological characteristics of dermatochalasis are consistent across different age groups.
- Lymphangiectasia, indicated by increased lymphatic vessel diameter, significantly progresses with age in patients with dermatochalasis.
