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Updated: Nov 18, 2025
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
Clinical Characteristics and Outcomes of Short-term Repeat Corneal Transplantation
Xiunian Chen1,2, Ting Li2, Xiaolin Qi2
1Medical College of Qingdao University, Qingdao, China.
Purpose:
To explore the primary indications, direct causes and graft survival of short-term repeat keratoplasty.
Methods:
An analytical cross-sectional study.
Results:
The primary indications for keratoplasty were infectious keratitis (67.9%) and immune keratopathy (12.8%). The direct causes of graft failure were infectious ulcer (43.6%) and recurrence (30.8%). Pre-operative hypopyon (P = 0.017, HR = 1.757) and use of decellularized porcine corneas as grafts (P = 0.005, HR = 2.690) were independent risk factors for graft failure. The Kaplan-Meier analysis revealed that the 1-year survival rate of 88 repeat grafts was 85.2%, and the 5-year survival rate was 79.2%. The survival rates of the repeat grafts were significantly higher than those of the first grafts (P < 0.001).
Conclusion:
Infectious keratitis is the most common indication of short-term graft failure and is often failed by infectious ulcer and keratitis recurrence. While the decellularized porcine cornea is a promising application in developing countries, certain difficulties, such as graft melting, remain unresolved.
