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Obstetric outcomes for twins from different conception methods - A multicenter cross-sectional study from China
Fang Jiang1, Jinsong Gao1, Jing He2
1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Acta Obstetricia Et Gynecologica Scandinavica
|February 8, 2021
Summary
Assisted reproductive technology (ART) increases maternal risks in twin pregnancies, including gestational diabetes and hemorrhage. However, ART does not independently affect neonate outcomes in twins.
Area of Science:
- Reproductive Medicine
- Maternal-Fetal Medicine
- Obstetrics
Background:
- Assisted reproductive technology (ART) use is increasing globally.
- The impact of ART on twin pregnancy outcomes remains debated.
- Understanding these risks is crucial for patient counseling and management.
Purpose of the Study:
- To compare maternal and perinatal outcomes of twin pregnancies conceived via spontaneous conception versus ART.
- To identify specific complications associated with ART-induced twin pregnancies.
Main Methods:
- Cross-sectional study utilizing the National Birth Registry of China (Oct 2016 - Sep 2017).
- Included twin pregnancies conceived spontaneously and through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).
- Logistic regression analysis was employed for multivariate comparisons.
Main Results:
- Higher incidences of gestational diabetes mellitus, preterm premature rupture of membranes, placenta accreta spectrum, and postpartum hemorrhage were observed in the IVF/ICSI group.
- Adjusted odds ratios indicated significant associations for these maternal complications.
- Conception mode was not found to be an independent risk factor for adverse neonatal outcomes.
Conclusions:
- ART is independently associated with increased maternal complications in twin pregnancies compared to spontaneous conception.
- Specific risks include gestational diabetes mellitus, preterm premature rupture of membranes, and placenta accreta spectrum.
- While maternal risks are elevated, ART does not appear to independently impact neonatal outcomes in twin gestations.
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