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Recent advances in peptide-targeted micelleplexes: Current developments and future perspectives.

Diana Costa1, Daniela Santo2, Cátia Domingues3

  • 1Univ Coimbra, Faculty of Pharmacy, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; Univ Coimbra, LAQV, REQUIMTE, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.

International Journal of Pharmaceutics
|February 8, 2021
PubMed
Summary
This summary is machine-generated.

Peptides enhance micelleplexes, a type of non-viral gene delivery system, to overcome biological barriers. This combination shows promise for advanced gene therapies targeting genetic diseases.

Keywords:
Co-deliveryGene deliveryMicelleplexesPeptidesPolymeric micellesPolymers

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Genetics

Background:

  • Human genome decoding advanced understanding of genetics in health and disease.
  • Exogenous nucleic acid therapies are crucial for treating genetic disorders.
  • Non-viral gene delivery systems, like micelleplexes, offer promising therapeutic options.

Purpose of the Study:

  • To review the use of peptides in conjunction with micelleplexes for gene therapy.
  • To analyze in vitro and in vivo studies on peptide-micelleplex systems.
  • To explore the potential and future perspectives of peptide-targeted micelleplexes.

Main Methods:

  • Micelleplexes, composed of amphiphilic block copolymers, form core-shell nanostructures.
  • Hydrophilic corona of micelleplexes carries nucleic acids; hydrophobic core carries drugs.
  • Peptides are utilized as targeting ligands due to their favorable characteristics.

Main Results:

  • Micelleplexes face in vivo barriers that limit their performance.
  • Peptides offer advantages like stability, affordability, and low immunogenicity.
  • Studies demonstrate the potential of combining peptides with micelleplexes for enhanced delivery.

Conclusions:

  • Peptide-functionalized micelleplexes represent a promising strategy for overcoming gene delivery challenges.
  • Further research into this combination holds significant potential for future gene therapies.
  • This approach could revolutionize the treatment of hereditary and acquired genetic diseases.