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Long non-coding RNA regulating androgen receptor signaling in breast and prostate cancer

Shashank Kumar1, Kumari Sunita Prajapati1, Atul Kumar Singh1

  • 1Department of Biochemistry, Drug Discovery and Therapeutic Laboratory, Central University of Punjab, Bathinda, 151401, India.

Cancer Letters
|February 8, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators in cancer development. This review highlights their role in gene expression and cancer, particularly in prostate and breast cancers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The human genome produces various non-coding RNAs that regulate gene expression.
  • Long non-coding RNAs (lncRNAs), transcripts over 200 nucleotides, are increasingly recognized for their roles in tumor development.
  • Aberrant lncRNA expression is linked to multiple human cancers, though their functions are still under investigation.

Purpose of the Study:

  • To review current knowledge on lncRNA expression patterns and their contribution to carcinogenesis.
  • To focus on lncRNAs involved in androgen receptor signaling pathways in prostate and breast cancers.
  • To discuss the prognostic and therapeutic implications of these lncRNAs.

Main Methods:

  • Literature review of recent studies on lncRNAs in cancer.
  • Analysis of lncRNA expression patterns and regulatory mechanisms.
  • Focus on lncRNAs impacting androgen receptor signaling.

Main Results:

  • lncRNAs play significant roles in various biological processes and disease stages.
  • Specific lncRNAs are aberrantly expressed in human cancers.
  • lncRNAs regulating androgen receptor signaling have prognostic and therapeutic relevance in prostate and breast cancer.

Conclusions:

  • lncRNAs are critical players in the development and progression of cancer.
  • Understanding lncRNA mechanisms, especially in androgen receptor signaling, offers potential for cancer diagnosis and treatment.
  • Further research into lncRNA functions is essential for advancing cancer therapy.
Keywords:
Androgen receptorLong non-coding RNAsProstate cancerSignaling pathwayTriple negative breast cancer

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