Related Experiment Video
Updated: Jul 21, 2026
12:42
Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
Published on: August 28, 2012
15.4K
Embryonal tumors with multilayered rosettes: A tertiary care centre experience.
1Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Clinical Neurology and Neurosurgery
|February 8, 2021
Summary
Embryonal tumors with multilayered rosettes (ETMR) are rare, aggressive pediatric brain tumors. Despite aggressive treatment, most patients succumb within one year, highlighting the need for improved therapeutic strategies.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Rare Cancers
Background:
- Embryonal tumors with multilayered rosettes (ETMR) represent a rare and highly aggressive group of central nervous system neoplasms.
- This category encompasses embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), and medulloepithelioma (MEPL).
Purpose of the Study:
- To report the institutional experience with seven cases of ETMR over a five-year period.
- To analyze the clinicopathological characteristics and treatment outcomes of ETMR patients.
Main Methods:
- Retrospective review of patient records from 2015 to 2019.
- Data collection included clinicopathological details and treatment outcomes for ETMR cases.
Main Results:
- Seven ETMR cases were identified, with a median age of four years.
- Surgery was performed in all cases, but only three patients completed adjuvant therapy (radiotherapy and/or chemotherapy).
- Six patients died within one year of diagnosis; only one patient receiving combined craniospinal irradiation and chemotherapy survived at 15 months.
Conclusions:
- ETMR is a rare and aggressive pediatric tumor with a poor prognosis.
- The majority of patients diagnosed with ETMR die within one year, even with multimodal treatment approaches.
