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HAND2-AS1: A functional cancer-related long non-coding RNA
Xinyu Gu1, Qiuxian Zheng1, Qingfei Chu1
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 8, 2021
Summary
Long non-coding RNA HAND2-AS1 generally suppresses tumor growth, but its role varies by cancer type. Aberrant HAND2-AS1 expression impacts tumor progression, prognosis, and cellular processes, highlighting its clinical significance.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are key regulators of gene expression and carcinogenesis.
- The lncRNA HAND2-AS1 (heart and neural crest derivatives expressed transcript 2 antisense RNA 1) has a complex role in cancer, often acting as a tumor suppressor.
- Its expression is frequently decreased in various cancers, but paradoxically upregulated in hepatocellular carcinoma, suggesting context-dependent functions.
Purpose of the Study:
- To review the expression profile, functions, underlying mechanisms, and clinical value of HAND2-AS1 in human cancers.
- To consolidate current knowledge on HAND2-AS1's involvement in tumor progression and prognosis.
- To analyze the expression patterns of HAND2-AS1 across a wide range of cancer types.
Main Methods:
- Literature review of studies investigating HAND2-AS1 in cancer.
- Bioinformatic analysis of HAND2-AS1 expression data from The Cancer Genome Atlas (TCGA) across 33 tumor types.
- Synthesis of data on HAND2-AS1's functional roles in proliferation, apoptosis, and metabolism.
Main Results:
- HAND2-AS1 expression is downregulated in most analyzed cancers (e.g., lung, ovarian, breast, gastric, colorectal, cervical, endometrial, prostate, esophagus).
- Conversely, HAND2-AS1 is upregulated in hepatocellular carcinoma, where it promotes tumor development.
- Aberrant HAND2-AS1 expression correlates significantly with tumor progression and patient prognosis.
- HAND2-AS1 influences critical cancer hallmarks including cell proliferation, differentiation, apoptosis, and glucose metabolism.
Conclusions:
- HAND2-AS1 exhibits diverse expression patterns and functions across different cancer types.
- Its dysregulation is closely linked to cancer development and clinical outcomes.
- HAND2-AS1 represents a potential biomarker and therapeutic target in oncology.
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