Related Experiment Videos
Atrioventricular septal defect in prenatal life
M V Machado1, D C Crawford, R H Anderson
1Department of Perinatal Cardiology, Guy's Hospital, London.
British Heart Journal
|March 1, 1988
Summary
Prenatal diagnosis of atrioventricular septal defects (AVSD) in fetuses is associated with a poor prognosis. Many cases involve chromosomal anomalies or atrial isomerism, often with severe cardiac complications and low survival rates.
Area of Science:
- Fetal Cardiology
- Medical Genetics
- Congenital Heart Disease
Background:
- Atrioventricular septal defects (AVSD) are complex congenital heart conditions.
- Prenatal detection allows for early assessment of fetal cardiac anomalies.
Purpose of the Study:
- To analyze the outcomes of fetuses diagnosed with atrioventricular septal defects (AVSD) prenatally.
- To identify associated anomalies and chromosomal abnormalities in fetuses with AVSD.
Main Methods:
- Retrospective review of over 3500 fetal echocardiograms.
- Identification and analysis of 29 cases with fetal atrioventricular septal defects (AVSD).
- Assessment of associated cardiac and chromosomal abnormalities, and patient outcomes.
Main Results:
- 29 cases of fetal atrioventricular septal defects (AVSD) were identified.
- Chromosomal anomalies (14/29) and atrial isomerism (14/29) were common findings.
- Prognosis was poor, with only 4 survivors out of 15 pregnancies reaching term.
Conclusions:
- Prenatally detected atrioventricular septal defects (AVSD) carry a high mortality rate.
- Associated conditions like chromosomal anomalies and atrial isomerism significantly impact prognosis.
- Early diagnosis necessitates careful counseling regarding the poor outlook for affected fetuses.