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Surface Membrane Barriers

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
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A Novel Transdermal Application for Clearing Skin Colonization by Candida auris.

M Ghannoum1, J Herrada2, Thomas S McCormick2

  • 1Center for Medical Mycology, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106 Mahmoud.ghannoum@case.edu.

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Novel topical agents effectively reduced Candida auris skin colonization in a mouse model. These findings suggest potential for preventing the spread of this opportunistic fungal pathogen in healthcare settings.

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • * *Candida auris* is an emerging multidrug-resistant yeast.
  • * Skin colonization by *C. auris* is a potential source of nosocomial infections.
  • * Understanding transmission routes is crucial for infection control.

Purpose of the Study:

  • * To evaluate the efficacy of two novel transdermal agents against *C. auris* skin colonization.
  • * To assess the potential of these agents in reducing fungal burden on the skin.

Main Methods:

  • * Development and optimization of a murine skin colonization model for *C. auris*.
  • * Treatment with 1% terbinafine or 1% clotrimazole formulated with Advanced Penetration Technology (APT™).
  • * Quantified fungal burden reduction compared to untreated control groups.

Main Results:

  • * Both terbinafine and clotrimazole formulations significantly reduced *C. auris* fungal burden.
  • * The APT™ formulation enhanced the delivery and efficacy of the antifungal agents.
  • * No significant difference was observed between the two active treatments in this model.

Conclusions:

  • * Novel transdermal agents containing terbinafine and clotrimazole show promise for clearing *C. auris* skin colonization.
  • * These agents could serve as a topical intervention to prevent the spread of *C. auris*.
  • * Further clinical studies are warranted to confirm efficacy in humans.