A Novel Transdermal Application for Clearing Skin Colonization by Candida auris

Area of Science:

• Medical Mycology
• Infectious Diseases
• Dermatology

Background:

• * *Candida auris* is an emerging multidrug-resistant yeast.
• * Skin colonization by *C. auris* is a potential source of nosocomial infections.
• * Understanding transmission routes is crucial for infection control.

Purpose of the Study:

• * To evaluate the efficacy of two novel transdermal agents against *C. auris* skin colonization.
• * To assess the potential of these agents in reducing fungal burden on the skin.

Main Methods:

• * Development and optimization of a murine skin colonization model for *C. auris*.
• * Treatment with 1% terbinafine or 1% clotrimazole formulated with Advanced Penetration Technology (APT™).
• * Quantified fungal burden reduction compared to untreated control groups.

Main Results:

• * Both terbinafine and clotrimazole formulations significantly reduced *C. auris* fungal burden.
• * The APT™ formulation enhanced the delivery and efficacy of the antifungal agents.
• * No significant difference was observed between the two active treatments in this model.

Conclusions:

• * Novel transdermal agents containing terbinafine and clotrimazole show promise for clearing *C. auris* skin colonization.
• * These agents could serve as a topical intervention to prevent the spread of *C. auris*.
• * Further clinical studies are warranted to confirm efficacy in humans.