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Related Concept Videos

Fatigue01:21

Fatigue

434
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
434
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
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Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Emerging Adulthood01:27

Emerging Adulthood

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Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
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Stress01:20

Stress

8.1K
When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...
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General State of Stress01:21

General State of Stress

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The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
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Updated: Nov 18, 2025

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

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Young and exhausted.

Filip Oleksak1, Peter Durdik2, Lubica Jakusova2

  • 1Department of Children and Adolescents, Martin University Hospital, Slovakia. oleksak.filip@gmail.com.

Advances in Respiratory Medicine
|February 9, 2021
PubMed
Summary
This summary is machine-generated.

Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in children can have surprising origins. Cardiopulmonary exercise testing helped diagnose a previously unrecognized cause in a pediatric patient.

Keywords:
cardiopulmonary exercise testingchronic fatigue syndromedysfunctional breathing

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Area of Science:

  • Cardiology
  • Pediatric Medicine
  • Neurology

Background:

  • Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is defined by prolonged, severe fatigue.
  • Diagnosing ME/CFS in pediatric patients requires excluding other treatable conditions.
  • Identifying the underlying cause is crucial for effective management.

Observation:

  • A pediatric case presented with symptoms consistent with ME/CFS.
  • Standard diagnostic procedures did not reveal an obvious cause.
  • The patient underwent cardiopulmonary exercise testing.

Findings:

  • Cardiopulmonary exercise testing identified a surprising, previously unrecognized organic origin for the patient's ME/CFS symptoms.
  • This diagnostic approach proved effective in uncovering a treatable condition.

Implications:

  • This case highlights the importance of advanced diagnostic tools like cardiopulmonary exercise testing in pediatric ME/CFS.
  • It suggests that ME/CFS in children may stem from diverse, sometimes unexpected, organic causes.
  • Early and accurate diagnosis through comprehensive testing can lead to timely and appropriate interventions.