The oncogenic and tumor suppressive roles of RNA-binding proteins in human cancers

Area of Science:

• Molecular Biology
• Cancer Biology
• Gene Regulation

Background:

• Posttranscriptional regulation controls gene expression via RNA molecules.
• RNA-binding proteins (RBPs) are key players in orchestrating RNA functions.
• Aberrant RBP regulation contributes to cancer initiation and progression through various mechanisms.

Purpose of the Study:

• To review the diverse roles of RBPs in cancer cell malignant transformation.
• To explore RBP involvement in multiple RNA regulation stages.
• To examine RBP interactions with microRNAs and long noncoding RNAs in cancer pathogenesis.

Main Methods:

• Literature review of studies on RBPs in cancer.
• Analysis of RBP functions in alternative splicing, RNA stability, polyadenylation, localization, and translation.
• Examination of interactions between RBPs and noncoding RNAs in cancer.

Main Results:

• RBPs influence cancer development through diverse mechanisms including genetic and epigenetic alterations.
• RBPs regulate multiple steps of RNA processing, impacting cancer progression.
• Interactions between RBPs and noncoding RNAs are significant in cancer pathogenesis.

Conclusions:

• RBPs are critical regulators in cancer development and progression.
• Understanding RBP functions and interactions provides insights into cancer pathogenesis.
• Targeting RBPs presents a promising avenue for cancer therapy.