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Updated: Nov 18, 2025
10:53
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
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Newer Non-ionic A2 B2 -Type Enzyme-Responsive Amphiphiles for Drug Delivery.
Krishna1, Badri Parshad1,2, Katharina Achazi3
1Department of Chemistry, University of Delhi, Delhi, 110007, India.
Chemmedchem
|February 9, 2021
Summary
New nonionic gemini amphiphiles were synthesized using a chemoenzymatic method. These novel structures show potential for drug delivery and stimuli-responsive guest release, demonstrating good cell viability.
Area of Science:
- Supramolecular Chemistry
- Polymer Chemistry
- Biotechnology
Background:
- Gemini amphiphiles offer unique self-assembly properties.
- Chemoenzymatic synthesis provides efficient and selective routes.
- Stimuli-responsive drug delivery systems are crucial for targeted therapies.
Purpose of the Study:
- To synthesize novel nonionic gemini amphiphiles with an A2B2 core.
- To investigate their aggregation behavior and nanotransport capabilities.
- To evaluate their stimuli-responsive release mechanisms.
Main Methods:
- Multi-step chemoenzymatic synthesis.
- Dynamic light scattering, fluorescence spectroscopy, and cryogenic transmission electron microscopy for aggregation studies.
- UV/Vis spectroscopy and fluorescence spectroscopy for guest encapsulation and release studies.
Main Results:
- Successful synthesis of novel nonionic gemini amphiphiles.
- Demonstrated aggregation in aqueous media and capacity for hydrophobic guest encapsulation (Nile Red, Nimodipine).
- Stimuli-responsive hydrolysis by esterases and lipase (Novozym 435) leading to guest release.
Conclusions:
- The synthesized amphiphiles are well-tolerated by A549 cells.
- Their ester-based structure enables stimuli-responsive guest release.
- These amphiphiles show promise as nanocarriers for hydrophobic drugs.
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