The Effects of Using Bioglue in Nasal Septal Surgery

Area of Science:

• Otolaryngology
• Surgical Innovation
• Biomaterials Science

Background:

• Nasal packs are crucial after septal surgery for hemostasis and stabilization.
• Exploring alternatives to nasal packing is essential for improving patient outcomes.
• Albumin-glutaraldehyde-based tissue adhesive (Bioglue) is a potential alternative.

Purpose of the Study:

• To evaluate the effects of Bioglue as a nasal pack alternative after experimental nasal septum surgery.
• To compare Bioglue's impact on nasal septal tissues against traditional nasal packs (Merocel).

Main Methods:

• 16 female Wistar albino rats underwent septoplasty.
• Bioglue was applied to the septal cartilage in the study group (n=10).
• Merocel nasal packs were used in the control group (n=6).
• Tissue samples were histologically analyzed at 2 and 4 weeks post-surgery for inflammation, cartilage damage, and other parameters.

Main Results:

• No instances of septal hematoma were observed in either group.
• All rats in the Bioglue group developed septal perforations.
• Significant foreign-body reactions, cilia loss, and goblet cell damage were noted in the Bioglue group.

Conclusions:

• Bioglue application resulted in segmental cartilage injury and septal perforation.
• These findings indicate Bioglue is not suitable for use as a nasal pack following septal surgery.
• Traditional Merocel nasal packs demonstrated a better safety profile in this experimental model.