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A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration
Hongjie Zhang1, Qiuquan Cai1, Yanhui Zhu1
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China. zhuwp@zju.edu.cn.
Biomaterials Science
|February 9, 2021
Summary
A novel, simple binary hydrogel combines injectability, adhesivity, and osteogenic activity for bone regeneration. Strontium-containing hydrogels effectively treated bone defects in animal models, showing promise for clinical applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Current hydrogels for bone regeneration often have complex compositions, hindering clinical translation.
- There is a need for injectable, adhesive, and osteogenic hydrogels with simplified production.
Purpose of the Study:
- To develop a simple, multifunctional binary hydrogel for bone regeneration.
- To evaluate the injectability, adhesivity, and osteogenic potential of the novel hydrogel.
Main Methods:
- Grafting dopamine (DA) onto alginate (Alg) to create Alg-DA.
- Forming an injectable hydrogel by mixing Alg-DA with strontium ions.
- Investigating in vivo crosslinking, tissue adhesivity, and osteogenic activity.
- Assessing bone defect healing in rat models.
Main Results:
- The binary hydrogel exhibited injectability and in vivo chemical crosslinking via catechol groups.
- The hydrogel demonstrated significant tissue adhesivity.
- Strontium ions conferred osteogenic activity, promoting bone defect healing in rats within 8 weeks.
Conclusions:
- A simple binary hydrogel composed of Alg-DA and strontium ions offers injectability, adhesivity, and osteogenic properties.
- This hydrogel shows potential as a scaffold for bone tissue engineering and clinical applications.
