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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

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Cancer and schizophrenia.

Merete Nordentoft^1,2,3, Oleguer Plana-Ripoll^4,3, Thomas Munk Laursen^4,3

¹CORE- Copenhagen Research Centre for Mental Health, Mental Health Center Copenhagen, Capital Region of Denmark, Copenhagen University Hospital.

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|February 9, 2021

Summary

Patients with schizophrenia face a 50% higher risk of cancer death. Early diagnosis, effective treatment, and smoking cessation programs are crucial to reduce this increased cancer mortality in this population.

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Area of Science:

Oncology
Psychiatry
Public Health

Background:

Schizophrenia diagnosis is associated with a significantly increased risk of cancer mortality compared to the general population.
Previous research indicates elevated mortality rates for specific cancers, including breast, lung, and colon cancer, in individuals with schizophrenia.

Purpose of the Study:

To estimate cancer incidence and excess mortality rates in patients with schizophrenia versus the general population.
To investigate the roles of underdiagnosis and undertreatment in the elevated cancer mortality observed in schizophrenia patients.

Main Methods:

Systematic review of articles published between 2018 and 2020.
Analysis of incidence rates and excess mortality data for overall and organ-specific cancers.
Exploration of diagnostic and treatment disparities.

Main Results:

Patients with schizophrenia exhibit a 50% increased risk of cancer-related death.
Increased mortality is confirmed for breast, lung, and colon cancers; incidence rates show mixed results.
Evidence suggests underdiagnosis and undertreatment contribute to higher cancer mortality, with lower chances of optimal colon cancer treatment.

Conclusions:

Individuals with schizophrenia face a heightened risk of cancer mortality, necessitating targeted interventions.
Strategies to reduce mortality include increased tobacco prices, systematic smoking cessation programs, and improved screening.
Facilitating access to early diagnosis and effective treatment is essential for this vulnerable group.