Related Experiment Video

Updated: Nov 18, 2025

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

21.3K

Acute rejection and growth outcomes in paediatric kidney allograft recipients treated with a corticosteroid

James McCaffrey1, Mohan Shenoy2

  • 1Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.

Pediatric Nephrology (Berlin, Germany)
|February 9, 2021
PubMed

Insights

Corticosteroid minimisation protocols (CMP) in pediatric kidney transplant recipients improve height, reduce obesity and hypertension without increasing acute rejection risk. This approach offers a safer long-term strategy for managing side effects.

Area of Science:

  • Pediatric Nephrology
  • Transplantation Immunology
  • Immunosuppression Therapy

Background:

  • Long-term corticosteroid use in pediatric kidney transplant recipients is associated with significant side effects.
  • Corticosteroid minimisation protocols (CMP) aim to reduce these adverse effects.
  • Evaluating the safety and efficacy of CMP in children is crucial for improving transplant outcomes.

Purpose of the Study:

  • To assess the incidence of acute rejection in children undergoing kidney transplantation with CMP.
  • To evaluate growth and long-term outcomes in pediatric kidney transplant recipients on CMP.
  • To compare outcomes of CMP with historical control groups.

Main Methods:

  • Retrospective analysis of pediatric kidney transplant recipients treated with CMP between 2009 and 2019.
  • Comparison of acute rejection rates and graft function with 5 control groups from recent studies.
  • Assessment of growth parameters, obesity, and hypertension at extended follow-up.

Main Results:

  • No significant difference in acute rejection rates between CMP-treated recipients and controls.
  • Graft function was lower in recipients experiencing acute rejection.
  • Children on CMP demonstrated improved height attainment, reduced obesity, and lower rates of hypertension compared to controls.

Conclusions:

  • Corticosteroid minimisation protocols (CMP) in pediatric kidney transplantation are safe and effective.
  • CMP is associated with better growth, reduced obesity, and decreased hypertension rates.
  • CMP offers a viable strategy to mitigate long-term side effects of immunosuppression in pediatric kidney transplant recipients.
Abstract

Keywords:
Acute rejectionCorticosteroidGraft lossImmunosuppressionPaediatric kidney transplantationTWIST

More Related Videos

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

16.5K
Robot-Assisted Kidney Transplantation07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.0K

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
147
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
172
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
155
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
429
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
718
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
285