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Nonischemic changes in right ventricular function on exercise. Do normal volunteers differ from patients with normal
J L Caplin1, M B Maltz, W D Flatman
1Department of Cardiology, St. Bartholomew's Hospital, London, England.
Clinical Cardiology
|March 1, 1988
Summary
Right ventricular function changes similarly in healthy individuals and cardiac patients during exercise. Some subjects experience decreased ejection fraction with exercise, unrelated to ischemia.
Area of Science:
- Cardiology
- Physiology
Background:
- Right ventricular (RV) function can be influenced by factors beyond ischemia.
- Left ventricular (LV) response to exercise differs between normal volunteers and cardiac patients with normal coronary arteries.
Purpose of the Study:
- To investigate changes in RV function during exercise in normal volunteers and patients with normal coronary arteries.
- To compare RV response to exercise between these two groups.
Main Methods:
- Utilized first-pass radionuclide angiography to assess RV function.
- Studied 21 normal volunteers and 13 patients with normal coronary arteries.
- Measured RV ejection fraction at rest and during exercise.
Main Results:
- Both groups showed a significant increase in RV ejection fraction on exercise.
- No significant difference in RV ejection fraction between groups at rest or during exercise.
- Found significant negative correlations between resting RV ejection fraction and exercise-induced changes in both groups.
- Older volunteers had lower resting and exercise RV ejection fractions.
Conclusions:
- Exercise-induced changes in RV function are comparable between normal volunteers and patients with normal coronary arteries.
- Observed decreases in RV ejection fraction during exercise in some individuals, independent of ischemic factors.