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Obsessive-Compulsive Disorder01:28

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Related Experiment Video

Updated: Nov 18, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Antisaccade task performance in obsessive-compulsive disorder and its clinical correlates.

Janardhanan C Narayanaswamy1, Aditi Subramaniam2, Anushree Bose2

  • 1Obsessive Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, India.

Asian Journal of Psychiatry
|February 9, 2021
PubMed
Summary

Obsessive-Compulsive Disorder (OCD) patients show greater errors in antisaccade eye movements, indicating cortico-striato-thalamo-cortical (CSTC) circuitry dysfunction. This deficit is independent of OCD symptom severity.

Keywords:
AntisaccadeCognitive functionsObsessive compulsive disorderResponse inhibition

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Ophthalmology

Background:

  • Obsessive-Compulsive Disorder (OCD) is linked to abnormalities in the brain's cortico-striato-thalamo-cortical (CSTC) circuitry.
  • Antisaccade eye movement tasks assess voluntary behavioral control, which is sensitive to CSTC circuitry function.

Purpose of the Study:

  • To investigate antisaccade eye movement parameters in individuals with OCD compared to healthy controls.
  • To determine the relationship between antisaccade performance and OCD symptom severity.

Main Methods:

  • Compared antisaccade performance in right-handed OCD patients (N=65) and matched right-handed healthy controls (HC, N=57).
  • Utilized an Eye-Link eye-tracker (1000-Hz sampling rate) to collect eye-tracking data during the task.
  • Assessed OCD symptom severity using the Yale-Brown Obsessive Compulsive Scale.

Main Results:

  • OCD patients exhibited a significantly higher percentage of antisaccade errors compared to HC (p < 0.001).
  • OCD patients demonstrated less accurate final eye positioning than HC (p < 0.001).
  • No significant correlations were found between antisaccade parameters and OCD severity measures.

Conclusions:

  • Impaired antisaccade task performance in OCD supports the hypothesis of CSTC circuitry abnormalities.
  • The observed deficits in antisaccade performance appear to be independent of OCD illness severity.
  • Further research in remitted OCD participants and unaffected relatives could validate endophenotype findings.