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A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of

Dimitris Tsoukalas1,2,3, Ovidiu Zlatian4, Mihaela Mitroi5

  • 1Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Journal of Clinical Medicine
|February 10, 2021
PubMed
Summary

This study shows that a novel nutraceutical supplement containing Centella asiatica, vitamin C, zinc, and vitamin D3 improved motor activity and reduced anxiety in aging rats. The supplement enhanced physical strength and quality of life in the elderly animal model.

Keywords:
Centella asiatica L.ageinganxiety levelsmotor performancevitamin Cvitamin Dzinc

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Area of Science:

  • Gerontology and Aging Research
  • Nutraceutical Science
  • Animal Models in Aging Studies

Background:

  • Aging is a natural process characterized by declining physiological functions and increased mortality.
  • Maintaining mobility and physical function is crucial for successful aging and quality of life in the elderly.
  • Nutraceuticals offer a potential avenue for mitigating age-related decline.

Purpose of the Study:

  • To evaluate the efficacy of a novel nutraceutical formulation (Reverse supplement) on motor activity and anxiety in aged rats.
  • To provide evidence for the potential clinical use of this supplement in the elderly to enhance physical strength and improve life quality.
  • To assess the dose-dependent effects of the supplement on age-related behavioral and physical changes.

Main Methods:

  • Eighteen 18-month-old male Sprague Dawley rats were divided into control and two treatment groups.
  • Rats received corn oil (control) or one of two doses of the Reverse supplement for 3 months.
  • Motor function and anxiety-related behaviors were assessed using the open-field, elevated plus-maze, and rotarod tests before and after treatment.

Main Results:

  • Supplementation with the Reverse supplement dose-dependently improved locomotor activity in aged rats.
  • Key indicators of improved motor function included increased latency to leave the center square, more rearings, and better performance on the rotarod test.
  • The supplement significantly reduced anxiety-like behaviors, evidenced by decreased grooming and altered time spent in specific zones in behavioral tests, in a dose-dependent manner.

Conclusions:

  • The novel nutraceutical formulation containing Centella asiatica, vitamin C, zinc, and vitamin D3 demonstrates significant benefits for motor activity and anxiety in aged rats.
  • These findings suggest the supplement's potential to enhance physical strength and improve the quality of life in the elderly population.
  • The observed dose-dependent effects support the targeted application of this nutraceutical for managing age-related functional decline.