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Updated: Nov 18, 2025

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
Published on: March 17, 2023
Metabolic Reprogramming, Questioning, and Implications for Cancer
Pierre Jacquet1, Angélique Stéphanou2
1TIMC-IMAG Laboratory, Grenoble Alpes University, CNRS UMR 5525, 38041 Grenoble, France.
Abstract:
The expression "metabolic reprogramming" has been encountered more and more in the literature since the mid-1990s. It seems to encompass several notions depending on the author, but the lack of a clear definition allows it to be used as a "catch-all" expression. Our first intention is to point out the inconsistencies in the use of the reprogramming terminology for cancer metabolism. The second is to address the over-focus of the role of mutations in metabolic adaptation. With the increased interest in metabolism and, more specifically, in the Warburg effect in cancer research, it seems appropriate to discuss this terminology and related concepts in detail.
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