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Updated: Nov 18, 2025

Quantifying Agonist Activity at G Protein-coupled Receptors
Published on: December 26, 2011
TFEB Biology and Agonists at a Glance
Mingyue Chen1, Yashuang Dai1, Siyu Liu1
1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310000, China.
Transcription factor EB (TFEB) agonists show promise for treating diseases linked to autophagy dysfunction. This review covers recent advances in TFEB biology and the development of TFEB agonists for therapeutic applications.
Area of Science:
- Cellular Biology
- Molecular Medicine
- Disease Pathogenesis
Background:
- Autophagy is vital for cellular homeostasis; its dysregulation contributes to cancer and neurodegenerative diseases.
- Transcription factor EB (TFEB) controls autophagy and lysosome function, impacting cellular clearance.
- TFEB's role in clearing pathogenic factors suggests therapeutic potential.
Purpose of the Study:
- To review the latest research on Transcription factor EB (TFEB) biology.
- To provide an overview of identified TFEB agonists and their therapeutic applications.
- To highlight TFEB modulation as a strategy for diseases involving autophagy dysfunction.
Main Methods:
- Literature review of TFEB biology.
- Analysis of recent studies on TFEB agonists.
- Compilation of preclinical and clinical trial data for TFEB agonists.
Main Results:
- TFEB is a master regulator enhancing autophagic and lysosomal pathways.
- Several TFEB agonists have been identified.
- TFEB agonists are under investigation in preclinical and clinical trials for various diseases.
Conclusions:
- Modulating TFEB activity presents a promising therapeutic avenue.
- TFEB agonists offer a potential strategy to address diseases associated with impaired autophagy.
- Further research into TFEB biology and agonists is crucial for developing novel treatments.
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