[Effect of nerve growth factor on synaptic processes in the sympathetic ganglion]

The nerves growth factor (7S NGF) from salivary glands of male mice activated the interneuronal relations in the inferior mesenteric plexus of 6-14-day old guinea-pigs. Superfusion of the ganglia with 7S NGF diluted to 1 X 10(-8) M (135 ng/ml) inhibited suppression of the acetylcholine release with hemicholinum or modified solutions. Atropine (1 X 10(-6) M) did not alter, and benzohexonium (1 X 10(-6) M) eliminated the excitatory effect of the 7S NGF Under d-tubocurarine (1 X 10(-6) M) blockade of H-cholinoreceptors, the 7S NGF decreased the MP and increased the duration blockade of synaptic transmission. Reduction of the tested protein effects in presence of potassium (K+ - 0.24 mM) and ouabain (1 X 10(-7) M) suggested the effect of the 7S NGF on processes of active and passive movements of electrogenic cations.