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Updated: Nov 18, 2025
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
High expression of NDRG3 correlates with poor prognosis in gastric cancer patients
Yun Liu1, Jinxuan Xia2, Yong Zhou3
1Digestuve Diseases, The Affiliated People's Hospital. Jiangsu University.
Introduction:
N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family and is linked with malignant tumors. However, the relationship between NDRG3 and gastric cancer (GC) is vague.
Material And Methods:
Western blot, qRT-PCR and immunohistochemistry (IHC) detected the expression of NDRG3 in GC cell lines and GC tissues; public databases were used to analyze NDRG3 in GC patients and the association with EBV infection.
Results:
NDRG3 was up-regulated in GC cell lines and tissues. IHC data suggested that NDRG3 was correlated with histologic grade (p = 0.006) and is associated with patient survival.
Discussion:
thus, NDRG3 may be a novel predictor of GC prognosis.
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