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[Neurodevelopmental Disorders, Psychiatric Comorbidities and Associated Pathologies in Patients with Childhood-Onset

A Fernandez1,2, M Pasquet-Levy1, G Laure1,2

  • 1Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpitaux Pédiatriques de Nice CHU-LENVAL, 57 avenue de la Californie, Nice, France.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|February 10, 2021
PubMed

Insights

Childhood-Onset Schizophrenia (COS) frequently presents with psychiatric and developmental issues, alongside somatic conditions like asthma. Early identification and management of these comorbidities are crucial for improving care quality in these young patients.

Area of Science:

  • Neuroscience
  • Child Psychiatry
  • Developmental Psychology

Background:

  • Childhood-Onset Schizophrenia (COS) is a rare, severe neurodevelopmental disorder with limited understanding of its associated conditions.
  • Comprehensive evaluation of comorbidities in COS is essential for effective patient management.

Purpose of the Study:

  • To investigate the psychiatric, neurodevelopmental, and somatic comorbidities in a cohort of children diagnosed with Schizophrenia.
  • To provide a detailed overview of the co-occurring conditions in Childhood-Onset Schizophrenia.

Main Methods:

  • An ancillary study utilizing standardized psychiatric interviews (K-SADS-PL DSM5) and neuropsychological assessments (WISC-V/WAIS-IV).
  • Detailed medical history collection including pregnancy, perinatal, developmental, and personal/family history was performed.
  • 20 outpatients diagnosed with Childhood-Onset Schizophrenia were included in the study.

Main Results:

  • High rates of psychiatric comorbidities were observed: Attention Deficit Hyperactivity Disorder (75%), Anxiety Disorders (70%), and Autism Spectrum Disorder (65%).
  • Neurodevelopmental issues included language delay and school career disruption in 90% of patients, with an average IQ of 70.26.
  • Asthma was the most frequent somatic comorbidity, affecting 75% of the patients.

Conclusions:

  • Childhood-Onset Schizophrenia is characterized by a high prevalence of psychiatric, neurodevelopmental, and somatic comorbidities.
  • Current management of COS is largely symptomatic; addressing all comorbidities is vital for enhancing overall patient care and quality of life.
  • Clinical practice should prioritize systematic screening and management of these associated disorders in children with Schizophrenia.
Abstract

Keywords:
ADHDautism spectrum disorderchild and adolescent psychiatrychildhood onset schizophreniacomorbiditydevelopmental disabilities

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