Feasibility of single-shot compressed sensing cine imaging for analysis of left ventricular function and strain in...

To compare single-shot compressed sensing (CS) cine imaging with conventional segmented cine imaging for reliable quantification of left ventricular (LV) volume and strain assessment during cardiac magnetic resonance imaging (CMRI).

Thirty-seven participants underwent both single-shot CS and conventional segmented cines that covered the entire LV. LV volumetric and strain values were obtained. LV volumes, global strain, the standard deviation of time to peak strain (SD-TPS) in the radial, longitudinal, and circumferential directions were compared using the Student's t-test and intraclass correlation coefficient (ICC). Interobserver and intra-observer variabilities of the LV strain values for the two cines method were determined using ICC.

Single-shot CS cine-derived LV volumes and myocardial mass measurements correlated strongly with segmented cines (ICC >0.798) and minor systematic end-systolic volume overestimations resulting in ejection fraction underestimations. Single-shot CS cine-derived global strain and SD-TPS were poorly to moderately correlated with segmented cines (ICC from 0.045-0.706). All global strain values derived from single-shot CS cines were underestimated compared with segmented cine-derived values; however, no significant differences in radial and longitudinal SD-TPS between the two cines were found. Among the patient-related factors, heart rate was a strong predictive factor of global longitudinal strain underestimations (p=0.039) in the CS cines. Inter- and intra-observer LV strain variabilities derived from CS and segmented cines were good to excellent.

Single-shot CS cine CMRI is feasible for the quantitative assessment of LV function. Currently, strain values derived from the two techniques are not interchangeable.