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Updated: Nov 18, 2025

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Acute Tracheal Necrosis After Intubation in a Childhood Onset Systemic Lupus Erythematosus
Brendan Burke1, William Tierney2, Rachel Georgopoulos2
1Department of Pediatric Critical Care, Cleveland Clinic Children's Hospital, Cleveland, OH.
Abstract:
Upper airway involvement in systemic lupus erythematosus (SLE) disease process is uncommon. A 15-year-old girl, a known patient with class IVA lupus nephritis, presented in acute renal failure due to flare-up of SLE. She underwent an uneventful elective intubation procedure for placement of a hemodialysis catheter. After 36 hours of extubation, she developed biphasic stridor and severe shortness of breath that was unresponsive to multiple medications. Prompt airway evaluation by laryngoscopy and confirmation of acute tracheal necrosis by histopathology along with reintubation and high-dose steroid therapy resulted in good outcome and recovery.
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