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Updated: Nov 18, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
A systematic review of reports of quality improvement for bronchopulmonary dysplasia
H Healy1, L E E Croonen2, W Onland2
1Boston Children's Hospital, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA.
Insights
Quality improvement efforts effectively reduce bronchopulmonary dysplasia (BPD) in preterm infants, especially those over 1000g. This systematic review highlights successful respiratory interventions for neonatal respiratory care.
Area of Science:
- Neonatal Medicine
- Pediatric Respiratory Medicine
- Healthcare Quality Improvement
Background:
- Bronchopulmonary dysplasia (BPD) remains the most common morbidity in preterm infants.
- Current research and interventions have not significantly reduced BPD incidence compared to other prematurity-related morbidities.
- Variability in BPD rates across institutions suggests potential for quality improvement (QI).
Purpose of the Study:
- To systematically review quality improvement (QI) efforts aimed at reducing BPD in preterm infants.
- To identify effective QI strategies and lessons learned from past interventions.
- To inform future research and QI initiatives for BPD management.
Main Methods:
- Systematic review of published reports on QI for BPD in preterm infants.
- Analysis of 22 single-center reports and 7 collaborative efforts over the past two decades.
- Evaluation of respiratory QI interventions and their impact on BPD rates and other respiratory outcomes.
Main Results:
- Respiratory QI interventions were successful in reducing BPD or other key respiratory measures in nearly all reviewed reports.
- Effectiveness was particularly noted in infants with a birth weight exceeding 1000 grams.
- Identified common themes and lessons from successful QI initiatives.
Conclusions:
- Quality improvement initiatives demonstrate significant potential for reducing BPD in preterm infants.
- QI interventions are a viable strategy to address the persistent challenge of BPD.
- Lessons learned can guide future research and implementation of QI to decrease the burden of BPD.
Abstract:
Bronchopulmonary dysplasia (BPD) is the most common morbidity of preterm infants, and its incidence has not responded to research and intervention efforts to the same degree as other major morbidities associated with prematurity. The complexity of neonatal respiratory care as well as persistent inter-institutional variability in BPD rates suggest that BPD may be amenable to quality improvement (QI) efforts. We present a systematic review of QI for BPD in preterm infants. We identified 22 reports from single centers and seven from collaborative efforts published over the past two decades. In almost all of the reports, respiratory QI interventions successfully reduced BPD or other key respiratory measures, particularly for infants with birth weight over 1000 g. Several themes and lessons from existing reports may help inform future efforts in both research and QI to impact the burden of BPD.
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