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Updated: Nov 18, 2025

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Multiorgan thromboembolic shower and its ethical implications
Amedra Basgaran1, Sayani Khara2, Aravinth Sivagnanaratnam2
1Stroke Medicine, Northwick Park Hospital, London North West University Healthcare NHS Trust, Harrow, UK a.basgaran@nhs.net.
A massive blood clot (thromboembolic shower) originating from the left ventricle caused widespread organ damage, including stroke and splenic infarction. This case highlights complex clinical and ethical challenges in managing critical illness.
Area of Science:
- Cardiology
- Vascular Surgery
- Nephrology
Background:
- A 54-year-old male presented with a suspected 5-day history of being found unresponsive at home.
- Initial diagnosis included non-ST elevation myocardial infarction, bilateral cerebral ischemic infarcts, and acute kidney injury secondary to rhabdomyolysis.
Observation:
- The patient developed bilateral lower limb ischemia the following day.
- A CT angiogram revealed extensive thromboembolism affecting lower limb arteries, pulmonary arteries, spleen, and mesentery.
Findings:
- Echocardiography identified a large left ventricular thrombus as the probable source of the thromboembolic shower.
- The widespread thromboembolic events led to recommendations for bilateral lower limb amputations.
Implications:
- This case presents significant clinical challenges in managing extensive thromboembolic disease.
- Ethical considerations regarding patient capacity and multidisciplinary decision-making are paramount in complex critical care scenarios.
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