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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
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Ocular surface squamous neoplasia: management and outcomes
Roland Hӧllhumer1,2, Susan Williams3, Pamela Michelow4
1Department of Neurosciences, Division of Ophthalmology, University of the Witwatersrand, Johannesburg, South Africa. roland.hollhumer@wits.ac.za.
Eye (London, England)
|February 10, 2021
Summary
Ocular surface squamous neoplasia (OSSN) management offers multiple options, including surgery and topical therapies like interferon, mitomycin-C, and 5-fluorouracil. These treatments show similar efficacy, with variations in cost and side effects.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Ocular surface squamous neoplasia (OSSN) is the most common ocular tumor.
- Incidence ranges from 0.03 to 1.9 per 100,000 persons/year.
- Diagnosis relies on clinical suspicion confirmed by AS-OCT, cytology, or histology.
Purpose of the Study:
- To review available management options for OSSN.
- To analyze the success and recurrence rates of different OSSN treatments.
Main Methods:
- Review of current literature on OSSN management.
- Comparison of surgical, topical (interferon-α2b, mitomycin-C, 5-fluorouracil), and other therapies.
- Analysis of efficacy, cost, and side effect profiles.
Main Results:
- Surgery is the gold standard for small OSSN lesions.
- Topical therapies (IFN, MMC, 5FU) demonstrate comparable resolution and recurrence rates.
- IFN has fewer side effects but is most expensive; MMC has higher toxicity; 5FU is cheapest with moderate toxicity.
Conclusions:
- OSSN benefits from diverse management strategies.
- No single modality is universally superior; combination therapy may be necessary.
- Novel therapies exist but lack widespread adoption due to cost and evidence gaps.
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