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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Predictive value of cardio-ankle vascular index for the risk of end-stage renal disease

Jin Seon Jeong1, Jung Hee Kim2, Dong Ki Kim3

  • 1Division of Nephrology, Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.

Clinical Kidney Journal
|February 10, 2021
PubMed

Insights

High cardio-ankle vascular index (CAVI), an arterial stiffness indicator, significantly predicts the risk of end-stage renal disease (ESRD). This finding highlights CAVI

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biomedical Engineering

Background:

  • Arterial stiffness is a known risk factor for cardiovascular morbidity and mortality.
  • The cardio-ankle vascular index (CAVI) is an emerging indicator of arterial stiffness.
  • The predictive value of CAVI for end-stage renal disease (ESRD) risk is not well-established.

Purpose of the Study:

  • To investigate the association between CAVI and the risk of developing ESRD.
  • To determine if CAVI can serve as a predictor for ESRD in a large patient cohort.

Main Methods:

  • A cohort of 8701 patients with measured CAVI using pulse wave velocity (PWV) was analyzed.
  • Patients were stratified into quartiles based on their CAVI values.
  • Cox proportional hazards models were used to calculate adjusted hazard ratios (HR) for ESRD, accounting for competing risks like death.

Main Results:

  • Over a median follow-up of 7 years, 203 cases of ESRD and 1071 deaths were recorded.
  • Patients in the highest CAVI quartile (fourth quartile) exhibited a significantly increased risk of ESRD compared to the lowest quartile (first quartile).
  • Adjusted HR for ESRD in the highest CAVI quartile was 2.46 (P < 0.001), and this association remained significant after adjusting for mortality (HR 2.35, P < 0.001).

Conclusions:

  • Elevated CAVI, indicative of arterial stiffness, is a significant independent predictor of ESRD risk.
  • CAVI measurement via PWV may be a valuable tool for identifying individuals at high risk for ESRD.
  • Further research may incorporate CAVI into risk assessment models for kidney disease.
Abstract

Keywords:
arterial stiffnesscardio-ankle vascular indexend-stage renal diseasemortalitypulse wave velocity

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