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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Calciphylaxis or vascular oxalosis?

Skye El-Saygeh1, Douglas Roese2, Sharon M Moe1

  • 1Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.

Clinical Kidney Journal
|February 10, 2021
PubMed
Summary
This summary is machine-generated.

Primary hyperoxaluria type 1 can cause severe vascular disease and limb loss due to calcium oxalate deposition. Kidney failure can rapidly worsen serum oxalate levels and vascular complications.

Keywords:
calciphylaxishyperoxaluriaoxalosisprimary hyperoxaluriaprimary hyperoxaluria type 1vascular oxalosis

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Area of Science:

  • Nephrology
  • Vascular Medicine
  • Genetics

Background:

  • Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder.
  • It leads to excessive oxalate production and deposition in kidneys and other organs.
  • End-stage kidney disease (ESKD) is a common complication of PH1.

Observation:

  • A 31-year-old female with PH1 and ESKD developed severe peripheral vascular disease (PVD).
  • The PVD led to limb amputation and was initially misdiagnosed as calciphylaxis.
  • Pathologic examination revealed calcium oxalate crystals within blood vessel lumens.

Findings:

  • The case highlights an unusual presentation of systemic oxalosis.
  • Calcium oxalate deposition in blood vessels caused severe PVD.
  • Acute kidney failure exacerbated serum oxalate levels and vascular issues.

Implications:

  • Elevated serum oxalate in PH1 patients has severe vascular consequences.
  • Prompt diagnosis and management of oxalosis are crucial.
  • Vascular complications can arise even with initial misdiagnosis.