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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Chronic Lymphocytic Leukemia of the Aortic Valve: A Case Report

Marie-Louise Posch1, Sean-Patrick A Prince1, Kevin Thompson1

  • 1Internal Medicine, Citrus Memorial Hospital, Inverness, USA.

Cureus
|February 10, 2021
PubMed

Insights

Chronic lymphocytic leukemia (CLL) can infiltrate atypical locations like the heart valve. This case highlights CLL involvement in aortic stenosis, emphasizing the need for broader diagnostic considerations.

Area of Science:

  • Hematology
  • Cardiology
  • Oncology

Background:

  • Chronic lymphocytic leukemia (CLL) is a common leukemia in Western countries, typically affecting lymphoid organs.
  • CLL infiltration of non-lymphoid tissues is rare, making diagnosis in such sites challenging.

Observation:

  • A 75-year-old male with CLL presented with cardiac symptoms, leading to the diagnosis of aortic stenosis.
  • Histopathological analysis of the patient's aortic valve revealed CLL infiltration.

Findings:

  • Immunohistochemical stains of the aortic valve tissue were positive for CD20, BCL2, CD5, and CD23.
  • These markers confirmed the presence of CLL within the cardiac valve.

Implications:

  • This case demonstrates an unusual presentation of CLL in cardiac tissue.
  • Investigating leukemic disease in patients with valvular conditions is crucial for comprehensive patient care and understanding CLL's potential atypical manifestations.

Keywords:
aorticcllleukemialymphocyticvalve

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