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Nonionic block polymer surfactants enhance immunogenicity of pneumococcal hexasaccharide-protein vaccines
G J Zigterman1, H Snippe, M Jansze
1Department of Immunology, State University of Utrecht, The Netherlands.
Infection and Immunity
|May 1, 1988
Abstract:
Incorporated in oil-in-water emulsions, nonionic block polymer surfactants change the kinetics of generated antibody responses against pneumococcal hexasaccharide-protein conjugates: prolonged immunoglobulin M and immunoglobulin G responses are realized. Nonionic block polymer surfactants favor the immunogenicity of hexasaccharide-protein conjugates in young mice in such a way that a single injection yields long-lasting protection.