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Related Concept Videos

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Related Experiment Video

Updated: Nov 18, 2025

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
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Endoscopic Ultrasound-Guided Celiac Plexus Interventions.

Pedro Moutinho-Ribeiro1,2, Pedro Costa-Moreira1,2, Ana Caldeira3

  • 1Gastroenterology Department, Centro Hospitalar e Universitário São João, Porto, Portugal.

GE Portuguese Journal of Gastroenterology
|February 10, 2021
PubMed
Summary

Endoscopic ultrasound-guided celiac plexus interventions offer significant pain relief for pancreatic diseases. These procedures, including celiac plexus block and neurolysis, are effective and have rare serious complications.

Keywords:
Celiac plexus blockCeliac plexus interventionsCeliac plexus neurolysisChronic painChronic pancreatitisPancreatic cancer

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Area of Science:

  • Gastroenterology
  • Interventional Endoscopy
  • Pain Management

Background:

  • Pancreatic diseases, such as chronic pancreatitis and pancreatic cancer, frequently cause severe, disabling abdominal pain.
  • Current pain management strategies may be insufficient for some patients, necessitating advanced interventions.

Purpose of the Study:

  • To provide an updated perspective on endoscopic ultrasound (EUS)-guided celiac plexus interventions for pancreatic pain.
  • To review selection criteria, technical aspects, safety, and efficacy of EUS-guided celiac plexus block (CPB) and neurolysis (CPN).

Main Methods:

  • Review of recent data on EUS-guided celiac plexus interventions.
  • Analysis of safety and efficacy in patients with pancreatic cancer and chronic pancreatitis.
  • Discussion of technique selection and patient criteria.

Main Results:

  • EUS-guided CPB and CPN provide significant pain relief in 50-80% of patients.
  • Efficacy rates are higher in pancreatic cancer (70-80%) compared to chronic pancreatitis (50-60%).
  • Serious complications are rare; common adverse events include transient diarrhea, orthostatic hypotension, and increased abdominal pain.

Conclusions:

  • EUS-guided celiac plexus interventions are effective and safe options for managing debilitating pancreatic pain.
  • CPN can be considered early in the management of inoperable pancreatic cancer.
  • These minimally invasive procedures represent a valuable therapeutic approach for selected patients.