Partial cognitive-dysmnesic seizures as a model for studying psychosis

Nineteen patients were analyzed who exhibited cognitive-dysmnesic psychic partial seizures and structural damage shown by means of CT scans. It was observed that these seizures originated in the amygdala-hippocampal system, coinciding with the effects found when using electrical stimulation of the brain. An attempt is made to relate these findings to the present biochemical hypotheses of schizophrenia, the kindling effect and the genetico-maturational hypotheses. All these data seem to agree and point in the direction of the possible neurophysiological mechanisms of psychosis and of schizophrenia in particular.