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Tailoring Materials for Modulation of Macrophage Fate
Jinhua Li1, Xinquan Jiang2, Hongjun Li3,4,5
1Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, 01307, Germany.
Advanced Materials (Deerfield Beach, Fla.)
|February 10, 2021
Summary
This review details how immunomodulatory biomaterials can be designed using materials science to control macrophage behavior for various therapeutic applications. These advanced materials offer new strategies for treating diseases and enhancing immune responses.
Area of Science:
- Biomaterials Science
- Immunology
- Materials Engineering
Background:
- The human immune system is crucial for tissue health and disease.
- Immunomodulatory biomaterials can manipulate innate and adaptive immunity for treatment.
- Macrophages play a central role in immune responses.
Purpose of the Study:
- To review design strategies for immunomodulatory biomaterials.
- To discuss how materials science principles regulate macrophage fate.
- To explore applications in immunoengineering.
Main Methods:
- Surveying material design principles for macrophage modulation.
- Analyzing physical, chemical, biological, and dynamic material cues.
- Examining biomaterial applications in various therapeutic areas.
Main Results:
- Material design can tune macrophage activation, polarization, migration, and secretion.
- Surface properties, topography, mechanics, composition, and dynamics are key modulators.
- Successful applications demonstrated in cancer, infection, regeneration, and vaccination.
Conclusions:
- Immunomodulatory biomaterials offer versatile strategies for immune system regulation.
- Tailoring biomaterial properties is essential for controlling macrophage responses.
- Future research directions focus on advancing immunoregulatory biomaterial applications.
