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Updated: Nov 18, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
A microwave-assisted copper-mediated tandem approach for fused quinazoline derivatives
Satyaveni Malasala1, Anusha Polomoni2, Sai Manohar Chelli3
1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India. nanduri.niperhyd@gov.in.
Abstract:
A method for the microwave-assisted copper-mediated oxidative coupling reaction of different aldehydes and quinazolines/benzimidazoles has been developed for the synthesis of fused-polycyclic systems via new C-N bond formation. The current methodology involves the use of environmentally benign NH4OAc as the amine source in the presence of 2-propanol as the solvent. This novel tandem reaction approach offers a rapid and straightforward access to complex fused quinazoline derivatives in an efficient manner.
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