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A simple screening method for insecticidal substances from actinomycetes.

B Fabre1, E Armau, G Etienne

  • 1Laboratoire de Recherches Cayla, Centre commercial de Gros, Toulouse, France.

The Journal of Antibiotics
|February 1, 1988
PubMed
Summary
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Researchers screened thousands of Actinomycetales strains for novel insecticidal compounds. A new insecticide producer, strain CL307-24, was identified from this screening, offering potential for new pest control agents.

Area of Science:

  • Microbiology
  • Chemical Ecology
  • Insect Toxicology

Background:

  • The search for novel insecticidal compounds is crucial for sustainable pest management.
  • Actinomycetales are a prolific source of bioactive natural products.
  • Existing screening methods often prioritize antimicrobial activity, potentially overlooking insecticidal producers.

Purpose of the Study:

  • To develop a selective assay for identifying insecticidal substances from Actinomycetales.
  • To screen a large collection of Actinomycetales strains for insecticidal activity.
  • To characterize novel insecticidal compounds and their producing microorganisms.

Main Methods:

  • A two-phase screening strategy was employed, starting with antimicrobial activity assessment.

Related Experiment Videos

  • Strains with weak or no antimicrobial activity were subjected to an insecticidal bioassay using Musca domestica (housefly) larvae and adults.
  • Active extracts underwent secondary screening for potency evaluation and preliminary biological identification of insecticidal products.

    • Main Results:

    • Out of 6,280 screened Actinomycetales strains, 47 showed activity, with 30 progressing to the second phase.
    • Most active strains produced known insecticidal metabolites like piericidins, avermectins, or valinomycin.
    • One strain, CL307-24, and its associated insecticide products were identified as novel.

    Conclusions:

    • A selective screening approach effectively identified insecticidal Actinomycetales.
    • Strain CL307-24 represents a novel source of insecticidal compounds.
    • Further investigation into strain CL307-24 and its products is warranted for potential agricultural applications.