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Influence of Lipid Membranes on α-Synuclein Aggregation

Andrii S Kurochka1,2, Dmytro A Yushchenko1,3, Petr Bouř1,2

  • 1Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Prague 166 10, Czech Republic.

ACS Chemical Neuroscience
|February 10, 2021
PubMed
Summary

Lipid membranes significantly delay alpha-synuclein (α-synuclein) fibril formation, a key process in Parkinson's disease. Membrane-bound α-synuclein monomers do not contribute to fibril elongation, slowing overall growth.

Keywords:
amyloidfibrilfibrillizationkineticslag timeliposomes

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