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Monocyte Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Expression Correlates with cIMT in Mexican

Ricardo Gamboa1, María José Jaramillo-Estrella1, María Del Rocio Martínez-Alvarado1

  • 1Instituto Nacional de Cardiologia Ignacio Chavez, Ciudad de México - México.

Arquivos Brasileiros De Cardiologia
|February 10, 2021
PubMed

Insights

Essential hypertension is linked to increased carotid intima-media thickness (cIMT) and higher expression of LRP1 mRNA and protein in monocytes. This suggests LRP1 upregulation may contribute to elevated cIMT in hypertensive patients.

Area of Science:

  • Cardiovascular Research
  • Molecular Medicine
  • Hypertension Studies

Background:

  • Arterial hypertension (HTA) is a significant risk factor for cardiovascular disease.
  • The precise molecular mechanisms underlying essential hypertension remain unclear.

Purpose of the Study:

  • To investigate the association between LRP1 monocyte expression (mRNA and protein) and carotid intima-media thickness (cIMT) in essential hypertension patients.
  • To explore the role of LRP1 in the development of hypertension-related cardiovascular changes.

Main Methods:

  • Quantified LRP1 monocyte mRNA and protein expression, and cIMT in 200 Mexican subjects (91 normotensive, 109 hypertensive).
  • Utilized statistical analysis with significance defined as p < 0.05.
  • Investigated the effect of Angiotensin II (Ang II) on LRP1 expression in monocytes.

Main Results:

  • Hypertensive patients exhibited significantly greater cIMT compared to normotensive individuals (p=0.002).
  • Increased LRP1 mRNA (6.54 vs. 2.87, p=0.002) and protein expression (17.83 vs. 6.25, p=0.001) were observed in hypertensive patients.
  • These associations persisted even when dyslipidemia was considered, and Ang II demonstrated a dose- and time-dependent induction of LRP1 on monocytes.

Conclusions:

  • Elevated cIMT in hypertensive subjects is associated with increased monocyte LRP1 mRNA and protein expression, independent of dyslipidemia.
  • LRP1 upregulation in monocytes may play a role in the increased cIMT observed in Mexican hypertensive patients.
Abstract

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