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Super-resolution Imaging of Neuronal Dense-core Vesicles
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VDAC-A Primal Perspective.

Carmen A Mannella1

  • 1Department of Physiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 20201, USA.

International Journal of Molecular Sciences
|February 11, 2021
PubMed
Summary
This summary is machine-generated.

The evolution of eukaryotic cells involved energy optimization through gene transfer and membrane expansion, leading to the development of the VDAC protein. This protein

Keywords:
VDACchemiosmosisendosymbiosisevolutionmembrane transportmitochondriaporin

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Area of Science:

  • Cell Biology
  • Evolutionary Biology
  • Biochemistry

Background:

  • Eukaryotic cell evolution involved endosymbiosis and energy optimization.
  • Gene transfer and membrane expansion increased adenosine triphosphate (ATP) production.
  • The host-endosymbiont interface faced selective pressure for energy advantage.

Purpose of the Study:

  • To hypothesize the role of a precursor β-barrel protein (pβB) in early eukaryotic evolution.
  • To propose that VDAC (voltage-dependent anion-selective channel) descended from pβB.
  • To explore the structural flexibility of VDAC as an inherited trait.

Main Methods:

  • Comparative analysis of protein structures.
  • Bioinformatic analysis of gene evolution.
  • Hypothetical modeling of protein function.

Main Results:

  • pβB likely managed critical functions at the host-endosymbiont interface.
  • VDAC evolved from pβB, retaining key functional properties.
  • VDAC's structural flexibility in gating is a proposed inherited trait.

Conclusions:

  • The adaptability of VDAC stems from its evolutionary origin.
  • Structural flexibility in VDAC's gating mechanism is crucial for its function.
  • Understanding VDAC's origins provides insight into eukaryotic cell evolution.