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The Key Role of Nucleic Acid Vaccines for One Health.
Anders Fomsgaard1, Margaret A Liu2
1Department of Virology and Microbiological Special Diagnostic, Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen, Denmark.
Viruses
|February 11, 2021
Summary
Plasmid DNA Nucleic Acid (NA) vaccines, crucial for One Health, demonstrate the power of gene-based vaccines. Understanding their attributes is key to efficacy and paved the way for mRNA vaccines.
Area of Science:
- * One Health and Zoonotic Disease Research
- * Vaccinology and Gene-Based Therapeutics
Background:
- * The SARS-CoV-2 pandemic underscored the significance of One Health principles, emphasizing pathogen transmission dynamics between animals and humans.
- * Gene-based vaccines, particularly nucleic acid (NA) vaccines, have emerged as a powerful tool in disease prevention.
Purpose of the Study:
- * To review the development of plasmid DNA Nucleic Acid (NA) vaccines.
- * To explain the importance of immunological and real-world attributes for NA vaccine efficacy.
- * To highlight the role of NA vaccines in paving the way for mRNA vaccine technology.
Main Methods:
- * Literature review of plasmid DNA Nucleic Acid (NA) vaccine development.
- * Analysis of immunological and real-world attributes influencing vaccine efficacy.
- * Examination of historical contributions to mRNA vaccine advancements.
Main Results:
- * Plasmid DNA NA vaccines have achieved licensure for veterinary applications and are under investigation for human diseases.
- * Understanding the specific attributes of NA vaccines is critical for optimizing their performance.
- * The development of NA vaccines provided foundational knowledge and technological advancements for subsequent mRNA vaccine platforms.
Conclusions:
- * Integrated efforts in vaccine development for both animal and human health are essential for technological progress.
- * Continued research into NA vaccines contributes to preparedness against emerging infectious diseases.
- * The success of NA vaccines validates the potential of nucleic acid-based platforms for future public health interventions.
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