Jove
Visualize
Contact Us

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

433
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
433
Tumor Progression02:07

Tumor Progression

6.9K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.9K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

178
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
178
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

831
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
831
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.7K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardioprotective Effects of Finerenone Associated With the Suppression of Myocardial Sodium Accumulation in Aldosterone/Salt-Loaded Rats.

Journal of the American Heart Association·2026
Same author

Effective RNA Delivery with Aggregation-Induced Lipid Backfolding.

ACS nano·2025
Same author

Stromal modifying CHST15 siRNA enhances antitumor effect synergistically with anti-PD-1 immune checkpoint antibody in murine pancreatic cancer.

Scientific reports·2025
Same author

Small-Molecule Therapeutics Achieve Multiple Mechanism-Mediated Sensitizations of Colorectal Cancer to Immune Checkpoint Blockade via Neutrophil Micropharmacies.

Nano letters·2024
Same author

Intra-tumoral administration of CHST15 siRNA remodels tumor microenvironment and augments tumor-infiltrating T cells in pancreatic cancer.

Molecular therapy. Oncology·2024
Same author

Discrepancies Between Morphological and Immunohistochemical Classifications Are Associated With Prognoses and Subtypes of Lung Cancer.

Anticancer research·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 18, 2025

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

699

Pathological Changes in Pancreatic Carcinogenesis: A Review.

Keiko Yamakawa1, Juanjuan Ye1, Yuko Nakano-Narusawa1

  • 1Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Cancers
|February 11, 2021
PubMed
Summary

Understanding early pancreatic cancer is crucial due to poor prognosis. This review summarizes pathological changes in humans and animal models during pancreatic carcinogenesis, aiding early detection and prevention strategies.

Keywords:
carcinogenesispancreatic cancerpathology

More Related Videos

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.1K
Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture
08:16

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture

Published on: February 11, 2019

9.1K

Related Experiment Videos

Last Updated: Nov 18, 2025

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

699
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.1K
Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture
08:16

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture

Published on: February 11, 2019

9.1K

Area of Science:

  • Oncology
  • Pathology
  • Gastroenterology

Background:

  • Pancreatic cancer has a dismal prognosis despite advances in diagnostics and therapeutics.
  • Lack of early detection methods and aggressive progression contribute to inoperable disease.
  • Characteristics of early pancreatic cancer remain poorly understood.

Purpose of the Study:

  • To review pathological changes during pancreatic carcinogenesis in humans and experimental animals.
  • To provide insights into risk factors, prevention, and novel diagnostic/treatment modalities.
  • To understand prediagnostic pancreatic malignancies and occult cancers.

Main Methods:

  • Review of autopsy studies identifying prediagnostic pancreatic malignancies.
  • Analysis of animal models (hamsters, genetically engineered mice) for carcinogenesis mechanisms.
  • Summary of pathological alterations in human and experimental animal pancreata.

Main Results:

  • Autopsy studies reveal characteristics of prediagnostic lesions and occult pancreatic cancers.
  • Animal models offer insights into carcinogenesis mechanisms, risk factors, and prevention.
  • Pathological changes during carcinogenesis are summarized for both humans and animals.

Conclusions:

  • Understanding early pathological changes is vital for improving pancreatic cancer prognosis.
  • Animal models are valuable preclinical tools for developing diagnostics and therapeutics.
  • Further research into early carcinogenesis can enhance early detection and prevention efforts.