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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.5K

Elevated circulating growth differentiation factor 15 is related to decreased heart rate variability in chronic

Lulu Wang1, Jing Luo1, Wenjin Liu2

  • 1Center for Kidney Disease, 2nd Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Renal Failure
|February 11, 2021
PubMed

Insights

Increased Growth Differentiation Factor 15 (GDF15) in chronic kidney disease (CKD) patients is linked to reduced heart rate variability (HRV). Further research is needed to understand GDF15

Area of Science:

  • Cardiovascular Research
  • Nephrology
  • Biomarkers

Background:

  • Growth Differentiation Factor 15 (GDF15) is a transforming growth factor beta superfamily member.
  • Elevated GDF15 levels are associated with cardiovascular disease risk.
  • The specific impact of GDF15 on the cardiovascular system in chronic kidney disease (CKD) patients requires further investigation.

Purpose of the Study:

  • To analyze the detailed effect of GDF15 on the cardiovascular system in patients with CKD.
  • To investigate the association between plasma GDF15 concentrations and cardiovascular parameters in CKD patients.

Main Methods:

  • Study included 355 non-dialysis CKD patients.
  • Assessed blood pressure, endothelial function, pulse wave velocity, and heart rate variability (HRV).
  • Measured plasma GDF15 concentration using enzyme-linked immunosorbent assay.

Main Results:

  • Higher plasma GDF15 concentrations correlated with decreased estimated glomerular filtration rate (eGFR) and increased urine protein-to-creatinine ratio (uPCR).
  • Multivariable analysis revealed a negative association between plasma GDF15 and HRV parameters (SDNN, RMSSD, Triangular Index).
  • Mean GDF15 level was 1394.7 (±610.1) pg/mL in participants with a mean eGFR of 50.1 (±33.2) mL/min/1.73m².

Conclusions:

  • A significant link exists between elevated plasma GDF15 and reduced heart rate variability (HRV) in CKD patients.
  • The underlying mechanisms and predictive value of GDF15 in cardiovascular disease within the CKD population warrant further study.
Abstract

Keywords:
GDF15chronic kidney diseaseheart rate variability

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