Persistent inflammation worsens short-term outcomes in massive stroke patients

Area of Science:

• Neurology
• Inflammation Research
• Clinical Outcomes

Background:

• Persistent inflammation is a known driver of disease progression and impacts prognosis.
• While inflammation indicators predict short-term outcomes, their role in massive stroke prognosis, particularly mortality, remains understudied.

Purpose of the Study:

• To investigate the association between persistent inflammation and prognosis in patients with massive stroke.
• To identify predictors of short-term outcomes in massive stroke.

Main Methods:

• Prospective enrollment of 139 massive stroke patients (April 2017-February 2020).
• Comparison of clinical, laboratory, and imaging data based on modified Rankin Scale (mRS) scores at 1 month.
• Binomial logistic analysis to determine independent predictors of 1-month prognosis.

Main Results:

• Higher admission blood glucose, cerebral hemispheric, posterior circulatory, and lacunar ischemia were observed in poor outcome patients.
• Neutrophil-to-lymphocyte ratio and blood glucose independently predicted short-term prognosis.
• Patients with persistent inflammation had higher rates of pulmonary infection, one-month mortality, and adverse outcomes.

Conclusions:

• Persistent inflammation is significantly associated with poor prognosis and increased 1-month mortality in massive stroke.
• Elevated baseline inflammation levels are predictive of short-term adverse outcomes and in-hospital pulmonary infections.