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Related Experiment Video

Updated: Nov 17, 2025

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
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Retinal Vascular Assessment in Psoriasis: A Multicenter Study.

Niccolò Castellino1, Antonio Longo1, Matteo Fallico1

  • 1Department of Ophthalmology, University of Catania, Catania, Italy.

Frontiers in Neuroscience
|February 11, 2021
PubMed
Summary
This summary is machine-generated.

Psoriasis patients show reduced retinal vascular density in both superficial and deep capillary plexuses, detectable by Optical Coherence Tomography Angiography (OCTA). These vascular changes may precede clinical signs of posterior eye inflammation.

Keywords:
maculaoptical coherence tomography angiographypsoriasisretinavascular changes

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Vascular Biology

Background:

  • Psoriasis is a chronic inflammatory disease with potential systemic manifestations.
  • Ocular involvement in psoriasis, though less common, can affect visual health.
  • Early detection of subclinical vascular changes in psoriasis patients is crucial for understanding disease progression.

Purpose of the Study:

  • To investigate the retinal vascular status in psoriasis patients without a history of ocular inflammation using Optical Coherence Tomography Angiography (OCTA).
  • To assess potential early vascular changes in the macula associated with psoriasis.

Main Methods:

  • A prospective, cross-sectional, multicenter study involving 55 psoriasis patients and 55 healthy controls.
  • Complete eye examinations and 6 mm × 6 mm OCTA imaging were performed.
  • Analysis included vascular density (VD) of superficial and deep capillary plexuses, foveal thickness (FT), and foveal avascular zone (FAZ).

Main Results:

  • Psoriasis patients exhibited significantly lower superficial and deep vascular density (wVD and pVD) compared to controls (p < 0.05).
  • These reductions were observed in both overall and parafoveal sectors.
  • No significant differences were found in best corrected visual acuity (BCVA), intraocular pressure, or refractive condition.

Conclusions:

  • Optical Coherence Tomography Angiography (OCTA) effectively reveals reduced retinal vascular density in psoriasis patients, even without ocular inflammation.
  • The observed vascular changes suggest that alterations in retinal vasculature may occur prior to the clinical manifestation of posterior uveitis in psoriasis.