Integrin, Exosome and Kidney Disease
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Updated: Nov 17, 2025

A Modified Precipitation Method to Isolate Urinary Exosomes
Published on: January 16, 2015
An-Ran Shen1, Xin Zhong1, Tao-Tao Tang1
1Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, China.
Abstract:
Integrins are transmembrane receptors that function as noncovalent heterodimers that mediate cellular adhesion and migration, cell to cell communication, and intracellular signaling activation. In kidney, latency associated peptide-transforming growth factor β (TGF-β) and soluble urokinase plasminogen activator receptor (suPAR) were found as the novel ligands of integrins that contribute to renal interstitial fibrosis and focal segmental glomerular sclerosis glomerulosclerosis (FSGS). Interestingly, recent studies revealed that integrins are the compositional cargo of exosomes. Increasing evidence suggested that exosomal integrin played critical roles in diverse pathophysiologic conditions such as tumor metastasis, neurological disorders, immunology regulation, and other processes. This review will focus on the biology and function of exosomal integrin, emphasizing its potential role in kidney disease as well as its implications in developing novel therapeutic and diagnosis approaches for kidney disease.
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