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Updated: Nov 17, 2025

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Pulmonary function tests in type 2 diabetes: a meta-analysis.

Jesús Díez-Manglano1, Uxua Asìn Samper2

  • 1Dept of Internal Medicine, Hospital Royo Villanova, Zaragoza, Spain.

ERJ Open Research
|February 11, 2021
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes (T2D) is linked to reduced lung function, impacting key measures like FEV1 and FVC. This association persists regardless of common factors such as sex, smoking, or BMI.

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Area of Science:

  • Pulmonology
  • Endocrinology
  • Public Health

Background:

  • Type 2 diabetes (T2D) is a growing global health concern.
  • Pulmonary function is crucial for overall health and quality of life.
  • The relationship between T2D and lung function requires further clarification.

Purpose of the Study:

  • To determine the association between type 2 diabetes and pulmonary function tests.
  • To quantify the impact of T2D on various lung function parameters.

Main Methods:

  • A comprehensive meta-analysis of 66 studies involving over 11,000 T2D patients and 48,000 controls.
  • Utilized random-effects models to calculate mean differences and 95% confidence intervals for lung function parameters.
  • Performed meta-regression and sensitivity analyses to explore heterogeneity and robustness of findings.

Main Results:

  • Significant reductions were observed in predicted percentages of FEV1, FVC, PEF, and DLCO in individuals with T2D.
  • No significant difference was found in the FEV1/FVC ratio.
  • Heterogeneity among studies was substantial but not explained by sex, BMI, smoking, or region.

Conclusions:

  • Type 2 diabetes is independently associated with impaired pulmonary function.
  • The findings underscore the need for longitudinal studies to understand the long-term outcomes for T2D patients with reduced lung function.