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Related Experiment Video

Updated: Nov 17, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Optimal hepatobiliary scintigraphy for gallbladder dyskinesia.

K F Flick¹, M Soufi¹, C M Sublette²

¹Department of Surgery, Indianapolis, IN.

Surgery Open Science

|February 11, 2021

Summary

A fatty meal is a cost-effective alternative to cholecystokinin for stimulating gallbladder contraction during hepatobiliary iminodiacetic acid scans, showing comparable accuracy in diagnosing biliary dyskinesia.

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Published on: March 24, 2023

Area of Science:

Gastroenterology
Nuclear Medicine
Diagnostic Imaging

Background:

Hepatobiliary scintigraphy accuracy for gallbladder function is debated.
Pharmaceutical-grade cholecystokinin shortages prompted fatty meal use for gallbladder stimulation.
This study compares cholecystokinin and fatty meal efficacy in gallbladder contraction assessment.

Purpose of the Study:

To compare the predictive indices of cholecystokinin (CCK) versus oral fatty meal (FM) for stimulating gallbladder contraction during hepatobiliary iminodiacetic acid (HIDA) scans.
To evaluate the diagnostic performance of CCK and FM in patients with biliary dyskinesia.

Main Methods:

Retrospective review of 359 patients undergoing HIDA scans from 2014-2017.
Patients were grouped by stimulant: CCK (n=273) or FM (n=86).
HIDA results correlated with surgical pathology and postoperative symptom resolution.

Main Results:

Mean gallbladder ejection fraction was 38% (CCK) vs. 44% (FM), P=.073.
No significant differences in predictive metrics for pathology, symptom improvement, or accuracy.
Symptomatic resolution (78% CCK vs. 68% FM) and specificity (26% CCK vs. 44% FM) were comparable.

Conclusions:

Fatty meal stimulation is a viable, affordable alternative to CCK for HIDA testing.
FM demonstrates comparable diagnostic value for gallbladder dysmotility evaluation.
This approach offers a reliable option amidst CCK supply issues.